Long-term clinical efficacy of grass-pollen immunotherapy
Article Abstract:
Grass-pollen immunotherapy for three or four years can prevent hay-fever in many patients. Researchers evaluated the incidence of hay-fever in 16 patients who had received grass-pollen immunotherapy for three or four years but then stopped the treatment. The rate of hay-fever symptoms and antihistamine use did not differ in these patients from 16 patients who continued to receive immunotherapy. Hay-fever symptoms and antihistamine use were also much lower than in a similar group of patients who never received immunotherapy.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
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Interferon gamma-1b compared with placebo in metastatic renal-cell carcinoma
Article Abstract:
Interferon gamma-1b does not appear to improve the prognosis of patients with a type of kidney cancer called renal-cell carcinoma. Researchers gave 181 patients with renal-cell carcinoma weekly injections of interferon gamma-1b or a placebo. All the patients had metastatic cancer and the primary tumor had been treated. Only 4.4% of those receiving interferon gamma-1b responded, compared to a 6.6% response rate in those receiving a placebo. Interferon gamma-1b did not reduce disease progression or improve survival rates.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
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Cancer immunotherapy with alloreactive lymphocytes
Article Abstract:
Immunotherapy using allogeneic lymphocytes requires ensuring the prevention of donor's T cell rejection and avoidance of toxicity and mortality inherent in the procedure. Infusions of allogeneic stem-cells without the abalation of the bone marrow cells has been found to be an effective treatment in patients with metastatic renal-cell cancer. The therapeutic importance of the procedure lies in the fact that the regression of metastases is delayed for months subsequent to the onset of graft-versus-host disease.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
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