Lymphocyte shedding from genital tract of human immunodeficiency virus-infected women: immunophenotypic and clinical correlates

Article Abstract:

Shedding of white blood cells from the genital tract may be more prevalent among HIV-positive women and may indicate a noninvasive method of obtaining white cell counts. Researchers analyzed genital tract samples of 43 HIV-positive women with a FACScan flow cytometer and found that 17 women (39%) shed white cells. No particular viral or treatment characteristics were found to be associated with white cell shedding. Women with CD4 cell counts below 500 were more likely to shed white cells, suggesting a local immune response of the genital tract to serious immune system compromise.

Lymphocytes, Reproductive organs, Female, Female genitalia

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Immunophenotypic characterization of human fetal liver hematopoietic stem cells during the midtrimester of gestation

Article Abstract:

Blood stem cells from aborted fetuses may be more incompatible as the fetus ages. These cells are being used more and more for transplantation because they are immature and may cause fewer complications. Fetal liver samples from 61 fetuses aborted mid-term were examined for numbers of blood stem cells and immune system markers that could potentially cause a transplant rejection. The number of immature blood cells was higher in older fetuses. However, the percentage of these cells expressing immune system markers, particularly CD123, also was higher in older fetuses.

Analysis, HLA histocompatibility antigens, HLA antigens, Hematopoietic stem cells, Gestational age

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Genital tract and plasma human immunodeficiency virus viral load throughout the menstrual cycle in women who are infected with ovulatory human immunodeficiency virus

Article Abstract:

The amount of HIV in a woman's genital secretions may increase around the time of ovulation even if her blood levels remain constant, according to a study of 14 HIV-infected women. This indicates that estrogen and progesterone may influence HIV reproduction in the genital tract. It also means that HIV-infected women may be more infectious during certain phases of their menstrual cycle than at other times.

Vagina

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