MET orchestrates cancer and blood coagulation
Article Abstract:
The study provides a model that can be systematically examined to identify the players and circuits that interconnect cancer and coagulation. Selectivity target tumor progression or coagulation can be evaluated for overall effects on pathogenesis, and new therapies can be assessed for efficacy.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Where lies the blame for resistance-tumor or host?
Article Abstract:
Study evidence based on cell-autonomous mouse model of drug resistance is presented. It suggests that cytokine signaling from the tumor microenvironment could permit leukemia cells to overcome drug treatment and survive targeted imatinib therapy.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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TORward AKTually useful mouse models
Article Abstract:
Cancer treatment is evolving to the precise deployment of molecularly targeted agents. Genetically engineered mice are useful to monitor therapy using molecular signature of target inhibition in tumor tissue.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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