Maternal and fetal cardiorespiratory responses to adenosine in sheep

Article Abstract:

Treatment with adenosine during pregnancy may not have a adverse effect on the cardiovascular system of a developing fetus. Adenosine is a substance that is used to treat tachycardia, or a rapid heart beat, in nonpregnant patients. A study examined the effect of intravenous and injected adenosine on the cardiovascular system of five pregnant ewes. Treatment with intravenous adenosine increased the heart rate and hemoglobin concentration of the ewes. Their diastolic and arterial blood pressure also dropped. Injected adenosine caused their diastolic blood pressure to drop. It also caused an abnormal maternal heart rate that alternated between slow and fast. Treatment with adenosine did not affect maternal blood gases or fetal heart rate, blood pressure or blood gases.

Circulatory system, Pregnancy, Cardiopulmonary system, Respiratory system

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Adenosine modulates corticotropin and cortisol release during hypoxia in fetal sheep

Article Abstract:

Adenosine appears to be involved in the increase in cortisol production during conditions of low oxygen levels. The medical term for low oxygen levels is hypoxia, and hypoxia in the fetal sheep stimulates the production of corticotropin by the pituitary gland, which in turn stimulates production of the adrenal hormone, cortisol. This is believed to help the fetus adapt to hypoxia. Researchers found that they could abolish the increase in corticotropin and cortisol during hypoxia in fetal sheep by giving them a drug that blocks the action of adenosine.

Hypoxia, Anoxia

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Maturation of cortisol responses to adrenocorticotropic hormone in twin fetal sheep in vivo

Article Abstract:

In twin pregnancies, the production of steroid hormones by the adrenal glands seems to occur earlier in one twin than the other. The production of steroid hormones by the adrenal glands is necessary for organ growth and maturation.

Hypothalamic-pituitary-adrenal axis, Twins

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