Maternal serum placental alkaline phosphatase level and risk for preterm delivery
Article Abstract:
Elevated placental alkaline phosphatase levels may signal an increased risk of preterm delivery. Placental alkaline phosphatase, a glycoprotein found in maternal serum, increases with gestational age and normally peaks at term. Placental alkaline phosphatase levels from serum samples of 1,868 pregnant women who had received serum alpha-fetoprotein screening were analyzed using a monoclonal antibody enzyme-linked immunosorbent assay. A total of 1,598 mothers delivered at term and 270 mothers had preterm deliveries. The odds of delivering preterm were determined greater among mothers with higher placental alkaline phosphatase levels. The elevated midtrimester serum levels among these mothers may indicate a breakdown of the fetal membranes.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
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Microsatellite analysis reveals a high incidence of maternal cell contamination in 46,XX products of conception consisting of villi or a combination of villi and membranous material
Article Abstract:
Genetics laboratories should be careful when examining embryonic tissue from a miscarriage because the tissue may be contaminated with maternal cells. In a study of 29 miscarriages, 26 of the aborted samples were contaminated with maternal cells and in 24, the fetal cells were completely obscured by the maternal cells. Therefore, any search for chromosomal abnormalities may be misleading.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
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A single physician's experience with four thousand six hundred genetic amniocenteses
Article Abstract:
Improvements in ultrasound technology, physician experience, and changes in technique make amniocentesis a safe procedure. Of 4,600 women who had amniocentesis performed by the same doctor over a 30-year period, less than 1% had a miscarriage from the procedure.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
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