Myopathy and spontaneous Pasteurella pneumotropica-induced abscess formation in an HIV-1 transgenic mouse model
Article Abstract:
A mouse model of HIV infection has been developed. Researchers used transgenic mice that had part of the HIV genetic material in their DNA. The resulting mice developed a severe eye infection shortly after birth. The infection was caused by an organism called Pasteurella pneumotropica, which is normally present in the respiratory tract of laboratory mice. HIV RNA was also found in lymph tissue, skeletal muscle and the lens of the eye. The mice also developed a progressive muscle disease, wasting and weight loss and died prematurely.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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An immunovirological study of central nervous system involvement during HIV-1 infection of chimpanzees
Article Abstract:
The central nervous system (CNS) of chimpanzees may not be affected by HIV-1 infection as it is in humans. In humans, HIV-1 affects the CNS early in the development of the infection with widespread production of antibodies. In a group of 18 HIV-infected chimpanzees, no virus was found in the cerebrospinal fluid and no anti-HIV-1 antibodies were detected even several years after infection. Chimpanzees may not get AIDS because of immunity to HIV-1 in their central nervous systems.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
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