Mechanisms of muscle wasting: the role of the ubiquitin-proteasome pathway

Article Abstract:

Muscle wasting has a lot to do with protein degeneration within the cell. An abnormally fast protein breakdown accounts for the loss of lean body mass characteristic of AIDS or cancer. Protein breakdown accelerates in response to fasting or a state of disease to generate amino acids necessary for energy. Since animal models of the ubiquitin-proteasome pathway have confirmed its role in wasting, developing drugs that inhibit pathway actions may prevent excessive weight loss. The use of hormones and steroids in this context remains controversial.

Physiological aspects, Weight loss, Cellular control mechanisms, Cell regulation, Muscle proteins, Ubiquitin

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Treating diabetic nephropathy--are there only economic issues?

Article Abstract:

Economic issues seem to be the primary considerations in discussions of treatment for nephropathy in patients with type 2 diabetes. The conclusion states that administering angiotensin-converting-enzyme (ACE) inhibitor can be an effective treatment for preventing or slowing down the damage from diabetic nephropathy.

Diabetic nephropathies

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Angiotensin-receptor blockade versus converting--enzyme inhibition in type 2 diabetes and nephropathy

Article Abstract:

A comparison is made between the renoprotective effects of angiotensin II-receptor blockers and angiotensin-converting--enzyme (ACE) inhibitors in persons with type 2 diabetes. It is found that telmisartan is not inferior to enalapril in providing long-term renoprotection in persons with type 2 diabetes.

Angiotensin receptors

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