Pharmacokinetics and pharmcodynamics of subcutaneous heparin during the early third trimester of pregnancy

Article Abstract:

Pregnant women may need larger doses of heparin than women who are not pregnant to achieve concentrations that can provide adequate blood anticoagulation. Researchers compared the action of heparin in six women in their third trimester of pregnancy and six non-pregnant women and found that the peak concentration was much lower in pregnant women. The concentration returned to normal much more quickly in pregnant women than in non-pregnant women, 285 minutes versus 480 minutes. Doctors treating pregnant women who need heparin may decide to start with a higher dose according to a woman's weight. The proper dosage for a pregnant woman may be determined by obtaining the peak heparin level two hours after injection, and the lowest level 280 minutes after injection.

Physiological aspects, Anticoagulants (Medicine), Anticoagulants, Dosage and administration, Heparin

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Thrombosis during pregnancy and the postpartum period

Article Abstract:

The circumstances surrounding deep vein thrombosis among pregnant or postpartum patients are described. The risk of deep vein thrombosis during pregnancy begins in the first trimester and hence, it is believed that when prophylaxis is indicated, it should be initiated early in gestation.

Science & research, Research, Thrombosis, Deep vein, Deep vein thrombosis, Puerperium

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Use of a new platelet function analyzer to detect von Willebrand disease in women with menorrhagia

Article Abstract:

The usefulness of a new platelet function analyzer in the detection of von Willebrand disease and platelet dysfunction in women with menorrhagia is assessed. The use of platelet analyzer was found to be helpful in detection of von Willebrand disease in women with menorrhagia.

Menorrhagia, Von Willebrand's disease

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