Molecular epidemiology of HTLV-I in the world
Article Abstract:
The prevalence of certain strains of human T-cell lymphotropic virus type 1 (HTLV-I) in specific geographical areas has illuminated specific human migrations in the past. HTLV-I is classified into three major strains: Melanesian, Central African and Cosmopolitan. Cosmopolitan is further broken down into subtypes A, B, C, and D. HTLV-I infection, once thought exclusive to Japan, Africa and the Caribbean, has now been found in other regions and ethnic groups. The slave trade can explain why the same subtype is found in West Africa and the Caribbean and other migrations show similar patterns.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Genetic variability and molecular epidemiology of human and simian T cell leukemia/lymphoma virus type I
Article Abstract:
The genetic stability of the human T-cell lymphotropic virus type I has allowed researchers to determine migration patterns in the recent and distant past. HTLV-I is classified into three major strains: Cosmopolitan, Central African and Melanesian. Cosmopolitan is further broken down into several subtypes. The clustering of different subtypes in different regions of the world illustrates the migration of different populations. For example, the slave trade between the 15th and 19th centuries has led to the presence of the same subtype in West Africa and the Caribbean.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
User Contributions:
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An HTLV-I/II vaccine: from animal models to clinical trials?
Article Abstract:
It is time to consider developing a vaccine against the human T-lymphotropic viruses, HTLV-I and HTLV-II. HTLV-I is widespread in Asia, parts of Africa and Central and South America. It causes adult T-cell leukemia/lymphoma and tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). These diseases can be fatal and up to 10% of the 15 million to 25 million HTLV-infected people worldwide could develop them. HTLV-II has been linked to diseases similar to TSP/HAM. A vaccine against HTLV could be very beneficial because the viruses are so stable genetically.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
User Contributions:
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- Abstracts: Molecular genetic etiolgy of twin reversed arterial perfusion sequence. Ultrasonographic measurement of the dividing membrane in twin pregnancy during the second and third trimesters: a reproducibility study
- Abstracts: Molecular biology of HTLV-I: recent progress. Simian T-lymphotropic virus type I infection among wild-caught Indonesian pig-tailed macaques (Macaca nemestrina)
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