Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals
Article Abstract:
The genetic modification of antigen-presenting cell lines which facilitate the production of CD[4.sup.+] and CD[8.sup.+] T lymphocytes specific for cytomegalovirus (CMV), Epstein-Barr virus (EBV) and several serotypes of adenovirus from a single cell culture is described. When administered to immunocompromised individuals, the single T lymphocyte line expands into multiple discrete virus-specific populations that supply clinically measurable antiviral activity.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Hitchhiker's guide to the T cell
Article Abstract:
A hitchhiking concept, in which tumor-specific T cells are surface-loaded with viruses that transfer immune-modulating genes to tumor cells, is described. In this strategy the T cells could provide targeting to the retrovirus vector, and the vector could encode or induce immune-stimulatory signals that promote T-cell activation and function.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia
Article Abstract:
The observation of sustained calcineurin activation in human-B and T-cell lymphomas showed that calcineurin activation is critical for the maintenance of the leukemic phenotype in vivo, as a identifying it as a pathway relevant to therapeutic target in lymphoid malignancies.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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