Mullerian inhibiting substance as a marker for ovarian sex-cord tumor
Article Abstract:
Women with sex-cord ovarian tumors may have higher levels of the hormone mullerian inhibiting substance (MIS) in their blood. Sex-cord ovarian tumors have cells similar to those found in sex cords, the fetal tissue that differentiates into ovaries before birth in females. The concentration of MIS in the blood of a patient with sex-cord ovarian tumors was 1,000 times the normal concentration in adults. The level of hormone decreased after the tumors were removed, and it increased each time the cancer re-occurred. Following the last surgery, the patient's MIS concentration was 10 times the normal adult level. A survey of 17 other patients with ovarian tumors found that the level of MIS was higher in those with sex-cord tumors. The concentration of MIS returned to normal when the women's tumors were removed. Sex-cord tumors appear to produce MIS, and their re-occurrence could be monitored by measuring blood levels of the hormone. Sex-cord tumors are rare; in one study, only 59 of 560,000 ovarian-biopsy samples reviewed were sex-cord tumors.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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Measurements of serum mullerian inhibiting substance in the evaluation of children with nonpalpable gonads
Article Abstract:
Measuring mullerian inhibiting substance in blood samples may identify male children with ambiguous genitalia. Mullerian hormone is necessary in girls for the production of the uterus and vagina but it must be inhibited in boys. Researchers measured mullerian inhibiting substance in 65 children with ambiguous genitalia or undescended testes. Levels were lower in children with no testicular tissue or abnormal testes compared to children with normal testes. The test was more effective than measuring blood levels of testosterone.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
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Sex determination and differentiation
Article Abstract:
The development of the sex organs and gene mutations that can affect this process are reviewed. Topics include male and female germ cells, syndromes of absent germ cells, gonadal and renal abnormalities, gonadal and adrenal abnormalities, SRY homeobox genes in gonadal dysgenesis, true hermaphroditism, Mullerian agenesis, persistent Mullerian duct syndrome, and congenital adrenal hyperplasia.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
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