Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men

Article Abstract:

Men with an inherited mutation of the blood coagulation factor V protein may have a higher risk of developing deep vein thrombosis or pulmonary embolism. These conditions are both caused by blood clots that develop in the large veins of the legs and lungs, respectively. To date, 704 male doctors being followed in the Physicians' Health Study have had a heart attack, stroke, deep vein thrombosis or pulmonary embolism. These men were matched to an equal number of men in the study who remain healthy. DNA analysis of factor V from blood samples revealed that 12% of the men who developed deep vein thrombosis or pulmonary embolism had the mutation, compared to 6% of those who had a heart attack, 4% of those who had a stroke and 6% of healthy men. Men with the mutation had no higher risk of a heart attack or stroke, but they had almost three times the risk of developing deep vein thrombosis or pulmonary embolism. Elderly men over 60 who had the mutation had seven times the risk of developing these conditions.

Genetic aspects, Pulmonary embolism, Blood coagulation factors, Thrombosis, Deep vein, Deep vein thrombosis

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Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism

Article Abstract:

Low-dose warfarin can lower the risk of recurring blood clots in some patients by up to 80%, according to a study of 508 patients. The patients were randomly assigned to receive a daily dose of warfarin that would produce an international normalized ratio (INR) of 1.5 to 2 or a placebo. The drug also lowered the risk of death, because four patients taking warfarin died compared to eight patients taking a placebo.

Evaluation, Warfarin

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Electronic alerts to prevent venous thromboembolism among hospitalized patients

Article Abstract:

Prophylaxis against deep-vein thrombosis in hospitalized patients remains underused. A computer program linked to the patient database is developed to identify consecutive hospitalized patients at risk for deep-vein thrombosis in the absence of prophylaxis.

United Kingdom, Drug therapy, Prophylaxis

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