Myoblast transfer in the treatment of Duchenne's muscular dystrophy

Article Abstract:

Injection of donated muscle cells called myoblasts into the muscles of people with Duchenne's muscular dystrophy does not appear to improve strength. People with Duchenne's muscular dystrophy lack the protein dystrophin in their muscles. For six months, 12 boys with Duchenne's muscular dystrophy received monthly injections of donated myoblasts into one arm and injections of saline into the other arm. The injections were in the biceps and the donated myoblasts were taken from a relative's biceps. Change in muscle strength was the same in both arms of the recipients. Cyclosporine, which was given to half of the recipients, had no impact on muscle strength. Antibody staining of muscle biopsies taken one year after the first injection showed low levels of dystrophin in four recipients. This indicates that the donated cells had fused with host cells and had produced dystrophin.

Care and treatment, Evaluation, Transplantation of organs, tissues, etc., Organ transplantation, Tissue transplantation, Transplantation, Cellular therapy, Cell therapy, Duchenne muscular dystrophy

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A 51-year-old woman with lung cancer and neuropsychiatric abnormalities

Article Abstract:

A 51-year-old woman with a history of small-cell lung cancer and the development of mental status changes and loss of sensation in her arms and legs was diagnosed with a sensory nervous system disorder caused by the cancer. This type of syndrome caused by cancer is called a paraneoplastic syndrome.

Paraneoplastic syndromes, Complications, Lung cancer, Small cell, Small cell lung cancer

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Case 16-2004: a 76-year-old woman with numbness and pain in the feet and legs

Article Abstract:

A case study of a 76-year-old woman, suffering from pain and numbness in feet and legs due to a small-fiber neuropathy, is presented.

United States, Diagnosis, Complications and side effects, Risk factors, Pain, Peripheral nerve diseases, Peripheral nervous system diseases

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