Neuronal PTP1B regulates body weight, adiposity and leptin action
Article Abstract:
A mice lacking PTP1B in specific tissues was generated to ascertain the cellular basis for the reduced adiposity, decreased weight gain on HFD, and increased activity and energy expenditure.The study of the mice generated show that neuronal PTP1B controls whole-body leptin sensitivity, and might be required for the development of leptin resistance and deficiency of PTP1B in the brain also affects production of leptin by adipocytes, glucose homeostasis and insulin sensitivity.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Stops along the RAS pathway in human genetic disease
Article Abstract:
Studies show that genetic disorders neurofibromatosis Type I, Noonan syndrome, LEOPARD syndrome, cardio-facio-cutaneous syndrome and Costello syndrome are caused by germline mutations in key components of the highly conserved RAS-RAF-ERK-MAP-kinase cascade, better known for its roles in growth factor and cytokine signaling and cancer pathogenesis. These finding have important implications for the diagnosis and therapy of this group of disorders.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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A role for the scaffolding adapter GAB2 in breast cancer
Article Abstract:
GAB2, the scaffolding adapter is usually amplified in human breast cancer and is overexpressed in breast cancer cell lines and primary tumors. The results prove that the agents targeting GAB2 and GAB2-dependant pathways can be of great help for treating breast tumors and can also play a great role in mammary carcinogenesis when overexpressed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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