Neutrophil adhesion to endothelial cells and factors affecting adhesion in patients with Behcet's disease
Article Abstract:
The immune properties of polymorphonuclear leukocytes (PMNLs) may play a role in the development of ulcers seen in the blood vessel linings of patients with Behcet's disease (BD). PMNLs are segmented white blood cells that adhere to immune complexes. Researchers studied the response of PMNLs and vessel lining cells to blood samples taken from patients with BD (study samples) as compared to blood samples taken from healthy volunteers (control samples). More PMNLs adhered to the lining cells in the presence of study sample blood (10.8%) as compared to control sample blood (8.9%). Treatment with antibodies to adhesion proteins reversed this adhesion to lining cells. A significantly greater proportion of PMNLs in study sample blood expressed a protein involved in adhesion called CD11a and contained an immune complex called interleukin-8 as compared to control samples.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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Interaction between synoviocytes and extracellular matrix in vivo
Article Abstract:
The relationship between the extracellular matrix of the innermost cell layer of the synovium and these cells may determine the growth of granulation tissue in joints. Synovium is the membrane that lines the cavity of a joint. The extracellular matrix regulates the function of the synovial intimal (innermost) cells, including their structure and growth. The proteins of the extracellular matrix may also control the production, adhesion, and invasion of these cells. Researchers examined the synovium of rheumatoid arthritis patients who were to have total knee replacement surgery for evidence of cell growth and structure. Certain substances may damage the protein, fibronectin, which exists in the extracellular matrix. The damaged fibronectin may in turn cause abnormal cell growth and structure.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis
Article Abstract:
Removing immune cells in the lining of joints that could damage the joint seems to prevent cartilage destruction in an animal model of rheumatoid arthritis. Researchers used liposomes containing the drug clodronate to remove immune cells in the knee joints of mice shortly before injecting them with a chemical that would cause arthritis. This treatment prevented cartilage destruction and an influx of other immune cells into the joint.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1998
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