Nucleotide polymorphism leads to reduced plasma factor levels
Article Abstract:
Japanese researchers have found a common polymorphism that causes the differences in the standard values of plasma levels of factor XII between Asians and Caucasians. They have found a high level of prevalence of 46 C to T substitution in Asians. This causes reduced levels of plasma FXII through low translation efficiency in hepatocytes among Asians. While the 46T polymorphism was identified in 73% of Asians, the 46C was found in 80% of Caucasians.
Publication Name: World Disease Weekly Plus
Subject: Health
ISSN:
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Quantity of latent virus correlates with reactivation
Article Abstract:
The reactivation rate and the site specificity of herpes simplex virus types 1(HSV-1) and HSV-2 are influenced by the amount of latent virus DNA. The latent amounts of HSV-1 and HSV-2 in the lumbosacral regions differ and so did the occurrence and frequency of infections. The anatomical regions affected by the two types also differ. While HSV-1 affects the oral-labial region, HSV-2 is more common in the genital region.
Publication Name: World Disease Weekly Plus
Subject: Health
ISSN:
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Novel mutation site may affect hemostasis
Article Abstract:
A previously unidentified mutation of the factor V gene at exon 7 has been found among Hong Kong Chinese. Factor V is a cofactor in the transformation of prothrombin to thrombin in the coagulation process which is related to the maintenance of hemostasis. Previously, G1691 to A mutation has been the only genetic abnormality found for the human factor V gene resulting in activated protein C resistance.
Publication Name: World Disease Weekly Plus
Subject: Health
ISSN:
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Multiple sclerosis: clues to diagnosis and recommended management. Avoiding misdiagnoses in upper-extremity infections
- Abstracts: Magic number: investing the accuracy of calorie readouts on cardiovascular fitness machines. Class struggle
- Abstracts: Students of hardship. Own up to envy: it's best for us all. Walks on the wild side: Nurses in Cardiff worked out that the best way to promote health was to get healthy, so they formed a successful walking group and used the money from sponsored walks to benefit their patients
- Abstracts: Full range of lymphoid proliferations are possible after transplantation. Alphacypermethrin-treated bednets may be cost effective for malaria prevention
- Abstracts: CDC sharpens tools for vaccine-safety surveillance. 2002 vaccine market: $7 billion. Unprecedented protection with prime/boost malaria vaccine