Organ transplantation-how much of the promise has been realized?
Article Abstract:
Improvements in immunosuppressive drugs and ancillary care have led to outstanding short-term patient and graft survival rates. Developing methods to induce transplant tolerance as a means to improve graft outcomes and eliminate the requirement for immunosuppression, and expanding the pool of organs for transplantation are the major challenges of the field.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha-1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
Article Abstract:
The initial results of the strategies of immune suppression and induction of tolerance using alpha-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach are reported. A life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels is achieved.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Allogenic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
Article Abstract:
Researchers were able to transplant bone marrow into mice without the need for myeloablative treatment. This was done by giving the mice a monoclonal antibody against CD154 and cytotoxic T-lymphocyte antigen 4 immunoglobulin.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The troubled transformation of Britain's National Health Service. What's happening to Britain's National Health Service?
- Abstracts: Freedom to practise: the doctor-nurse relationship. Freedom to practise: changes in daily practice. Freedom to practise changing ward culture
- Abstracts: Logic of overseas recruitment is warped. Called to account
- Abstracts: China's first international HIV vaccine meeting: the war of the roses. Fate of 'Montagnier center' to be decided
- Abstracts: Tiramisu temptation. Season's eatings. Just for the halibut: changing your mind about hating fish