Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cell
Article Abstract:
The potential role of bone-resorbing osteoclasts in homeostasis and stress-induced mobilization of hematopoietic progenitors is investigated. Different stress situations activity of osteoclasts (OCLs) along the stem cell-rich endosteum region of bone, secretion of proteolytic enzymes and mobilization of progenitors.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
PPAR-[gamma] regulates osteoclastogenesis in mice
Article Abstract:
The pro-osteoclastogenic effect of peroxisome proliferator-activated receptor-[gamma] (PPAR-[gamma])A is examined by using aTie2Cre/flox mouse model. Results described a major role for PPAR-[gamma] and its ligands in promoting osteoclast differentiation and bone resorption.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Genetic deficiency in Pparg does not alter development of experimental prostate cancer
Article Abstract:
Results demonstrate that neither deletion of the nuclear peroxisome proliferator-activated receptor-gamma nor its total ablation influence prostate cancer development in a mouse model.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Medical implications of the male biological clock. Disease management and the organization of physician practice
- Abstracts: The use of compound topical anesthetics. Microbial contamination of toothbrushes with different principles of filament anchoring
- Abstracts: Just how far can healthy schools go? Linking education and mental health - a European priority . Delivering health education: the contribution of social and emotional learning
- Abstracts: The future of dementia care. HPV vaccination of girls to help prevent cervical cancer. Improving vitamin D levels in pregnancy and breastfeeding
- Abstracts: The use of pastoral and spiritual support in bereavement care