Outcome at Age 4 Years in Offspring of Women With Maternal Phenylketonuria: The Maternal PKU Collaborative Study
Article Abstract:
Women with phenylketonuria (PKU) should begin eliminating phenylalanine from their diet completely as soon as they know they are pregnant. In a study of 253 pregnant women, 149 with severe PKU were started on a restricted diet, whereas 33 with mild PKU and 71 with no history of PKU were not treated. By the age of 4, 47% of the children whose mothers received no treatment for PKU or were not adequately treated scored low on tests of intellectual ability. Overall, almost one-third of the children born to women with PKU had social and behavioral problems.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
The International Study of Pregnancy Outcome in Women with Maternal Phenylketonuria: report of a 12-year study
Article Abstract:
Pregnant women with phenylketonuria who eat a diet free of phenylalanine can substantially reduce the risk of damage to their baby. This was the conclusion of a 12-year follow-up of 576 women with phenylketonuria, a metabolic disease that can cause mental retardation.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Effect of expanded newborn screening for biochemical genetic disorders on child outcomes and parental stress
Article Abstract:
Expanded newborn screening for up to 20 different metabolic disorders may improve the health of children who test positive, according to a study of 258 children. However, children who have a false positive test may be hospitalized unnecessarily and their parents may be overly stressed. A false positive test means a diagnostic test is positive but the person who was tested doesn't really have the disease.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Politics: one in three nurse voters say they trust Labour, but only 5% trust the Conservatives. New year, new image
- Abstracts: Antiretroviral Therapy in Adults: Updated Recommendations of the International AIDS Society--USA Panel. Treatment for adult HIV infection
- Abstracts: Identification and functional importance of plasma kallikrein in the synovial fluids of patients with rheumatoid, psoriatic, and osteoarthritis
- Abstracts: Estimated Incidence and Prevalence of Genital Chlamydia trachomatis Infections in the United States, 1996. HIV Prevalence in Patients With Syphilis, United States