P12Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
Article Abstract:
The use of inhibitors of phosphoionositide 3-kinase (PI3K) gamma, a lipid kinase that regulates inflammation, in the MRL-Ipr mouse model of systemic lupus erythematosus (SLE) is examined. Treatment reduced glomerulonephritis and prolonged lifespan, suggesting that P13Kgamma might be a useful target in the treatment of chronic inflammation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
Article Abstract:
Extracellular periostin has induced the reentry of differentiated mammalian cardiomyocytes into the cell cycle. It is shown that periostin and the pathway that it regulates have provided a target for innovative strategies to treat heart failure.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development
Article Abstract:
Mice who are deficient in the cell-cycle regulator p21 develop symptoms similar to women who have lupus. The symptoms include autoantibodies against dsDNA, lymphadenopathy, glomerulonephritis, and decreased viability.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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