Statins and Fracture Risk

Article Abstract:

More clinical trials are needed to determine whether a class of cholesterol-lowering drugs called statins can lower the risk of bone fractures in elderly people. Several studies have provided such evidence but they were all observational studies rather than controlled clinical trials.

Health aspects, Editorial, Bones, Fractures (Injuries), Fractures, Anticholesteremic agents

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Retrospective drug utilization review, prescribing errors, and clinical outcomes

Article Abstract:

Retrospective drug utilization review does not appear to reduce the number of medication errors or improve the health of patients, according to researchers who analyzed the data from six Medicaid programs that use the same software program to analyze drug prescription patterns. This review has been required by law since 1969 but has never been evaluated. It is also being considered in the proposed Medicare drug benefit plan.

Drugs, Medical care, Medical care utilization, Prescriptions (Drugs), Medication errors

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Parenteral ketorolac and risk of gastrointestinal and operative site bleeding: a postmarketing surveillance study

Article Abstract:

Surgeons can minimize the adverse effects of the non-steroidal anti-inflammatory drug ketorolac by administering smaller doses of the drug intravenously for shorter periods of time. Researchers followed the incidence of gastrointestinal and operative site bleeding in 9,900 patients undergoing surgery at 35 hospitals who received intramuscular or intravenous ketorolac. The results were compared to 10,247 patients who received intravenous opiates. The overall incidence of gastrointestinal bleeding was 4% in those receiving ketorolac and 3.6% in those receiving opiates. Life-threatening bleeding occurred during 2.1% of ketorolac infusions and 1.9% of opiate infusions. Bleeding at the operative site occurred during 39.6% of ketorolac infusions and 38.6% of the opiate infusions. Fewer than 2% of the cases of operative site bleeding in both groups were serious. Ketorolac doses greater than 90 milligrams per day for five days or more were associated with a higher rate of complications, especially in the elderly.

Complications and side effects, Risk factors, Gastrointestinal bleeding, Gastrointestinal hemorrhage, Surgery, Postoperative complications, Nonsteroidal anti-inflammatory drugs, Nonsteroidal anti-inflammatory agents

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