Pathogenesis of HIV infection: What the virus spares is as important as what it destroys
Article Abstract:
HIV targets CCR5+CD4+ effector memory T cells, resulting in acute, massive depletion of these cells from mucosal effector sites upon transmission to a new host. This depletion does not initially compromise the regenerative capacity of the immune system because naive and most central memory T cells are spared and that frequent activation of these spared cells during the chronic phase of HIV infection supplies mucosal tissues with short-lived CCR5+CD4+ effector cells that prevent life-threatening infections.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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HIV-1-specific CD4(super.+) T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
Article Abstract:
HIV-1-specific CD4(super.+) T cells can be detected in most persons with active HIV-1 infection, but they decline with prolonged viral suppression. Flow cytometric detection of antigen-induced intracellular cytokines was used to show that significant frequencies of gag-specific, T-helper-1 CD4(super.+) memory T cells are detectable in most subjects with active/progressive HIV-1 infection.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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Ongoing HIV dissemination during HAART
Article Abstract:
A model of HIV replication is presented to explain why antiretroviral drugs do not completely eradicate the virus from the body. HIV replication may occur in bursts in various tissues and drugs can reduce the size of the burst but not completely abolish it.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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