Pharmacokinetics of ampicillin and sulbactam in pregnancy
Article Abstract:
Pregnant women and women who have just given birth may metabolize certain antibiotics more quickly than other individuals. Among 22 pregnant women who underwent a cesarean section, 12 were treated intravenously with one gram (gm) of ampicillin and 10 were treated intravenously with one gm of ampicillin and 0.5 gm of sulbactam at the time of the cesarean section and six weeks after delivery. The women's blood levels of ampicillin dropped at a significantly faster rate at the time of the cesarean section than at six weeks after delivery. Blood levels of sulbactam also dropped at a slightly faster rate at the time of the cesarean section than at six weeks after delivery. Women who are pregnant or who have just given birth should be treated with more frequent doses of beta-lactam drugs.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1993
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The effect of timing of single-dose transplacental ampicillin-sulbactam therapy for prevention of neonatal group b streptococcal colonization and bacteremia in a rabbit model
Article Abstract:
Antibiotic treatment given to female rabbits soon before delivery appears to provide a protective benefit to pups infected with group B streptococcus at delivery. Fourteen pregnant rabbits were injected with ampicillin-sulbactam and 13 pregnant rabbits received no treatment two to eight hours before labor was induced. Newborn pups were infected orally with group B streptococcus. Pups of treated mothers were less likely to test positive for the infection in the heart, throat, and anus and were more likely to survive to 48 hours. Infection rates were lowest among pups of mothers treated three to five hours before birth.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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Inhibition of amniotic prostaglandin E release by ampicillin
Article Abstract:
Some antibiotics may prolong premature labor by inhibiting the release of prostaglandin E in fetal membranes. Premature labor has been linked to bacterial infection and some studies have shown that antibiotics can prevent premature labor. Researchers tested the effect of the antibiotic ampicillin on prostaglandin release in cultures containing fetal membranes. The antibiotic inhibited prostaglandin E release, which would delay labor even in the absence of infection.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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