Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration
Article Abstract:
Some of the mechanisms that are proposed for sporadic Alzheimer's disease (AD) pathogenesis are reviewed. An evaluation of the possibility that altered presenilin activity may perturb processes and perhaps, in turn, contribute to neurodegeneration in the nongenetic or age-associated cases of sporadic AD.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Peroxiredoxin-2 links Cdk5 to neurodegeneration
Article Abstract:
The role of cyclin-dependent kinase 5 (Cdk5), a serine/threonine kinase, to the neurodegenration in Parkinson's disease is examined. Researchers have shown that the inactivation of peroxiredoxin-2 (Prx2) by Cdk5 might be relevant to the pathogenesis of Parkinson's disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Polyglutamine neurodegeneration: minding your Ps and Qs
Article Abstract:
The effect of the neurodegenerative disorder caused by abnormal protein accumulation and aggregation is illustrated. It is assumed that the polyglutamine triggers the disease process to form an isolated polyglutamine that is toxic to neurons.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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