Prenatal care of HIV-infected women: analysis of a large New York state cohort

Article Abstract:

Prenatal care of HIV infected women may be increased by drug addiction treatment and longer Medicaid enrollment. Researchers analyzed the medical records of 2,254 HIV infected women enrolled in New York State Medicaid who had single babies between 1985 and 1990. According to the Kessner Index on sufficient number of prenatal visits, 65% of the women had too few prenatal visits. Fifty-five percent of the non-drug users, 67% of the methadone-treated women, and 76% of illegal drug users had too few visits. Of the women who were enrolled in Medicaid for less than 25% of their pregnancy, 73% had too few prenatal visits. About two-thirds of the African-American and Latina women and one half of the Caucasian women had too few prenatal visits. Some studies have shown that treating HIV infected pregnant women with zidovudine may reduce the risk infecting the child. Thus improving prenatal care coverage is important.

Demographic aspects, Pregnancy, Prenatal care, HIV infection in pregnancy

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Active anti-interferon-alpha immunization: A European-Israeli, randomized, double-blind, placebo-controlled clinical trial in 242 HI-1-infected patients (EURIS Study)

Article Abstract:

Vaccinating HIV patients against excessive levels of interferon alpha may prevent some complications of AIDS. Interferon alpha is a naturally occurring immune system protein, but excessive levels produced during HIV infection are believed to be damaging. Researchers gave 242 HIV patients three doses of an anti-inferferon alpha vaccine or a placebo at one-month intervals, followed by booster shots every three months. Only 33% of the patients who received the vaccine developed an immune response that would control their interferon alpha levels. The vaccine did not seem to affect the progression of HIV infection, but reduced the rate of complications.

Physiological aspects, Vaccination, Interferon alpha

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A preliminary study to determine the effect of an infusion of cryopreserved autologous lymphocytes on immunocompetence and viral load in HIV-infected patients

Article Abstract:

An autologous infusion of CD8 lymphocytes may boost the immune system in people with HIV infection. Autologous transfusions occur when a patient donates blood and then receives it back at a later time. The CD8 lymphocyte appears to be active in fighting HIV infection. Researchers evaluated 12 HIV-infected patients who donated CD8 lymphocytes early in the infection and then received their own donated lymphocytes back later on in the infection. These transfusions raised T cell levels and lowered viral levels in seven patients. In two patients, T cell levels rose to the level seen at the time of the donation.

Evaluation, Lymphocytes, Blood transfusion, Autologous, Autologous blood transfusion

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