Prevention of hepatitis B virus transmission by immunization: an economic analysis of current recommendations
Article Abstract:
Infant vaccination for the hepatitis B virus (HBV) is more cost effective and useful in preventing HBV infection transmission than adolescent vaccination. The strategy to delay vaccination for HBV until adolescence would increase costs for each infection prevented. An estimated 2,243 chronic hepatitis B infections could be prevented with adolescent immunization, but 6,564 chronic infections occurring in early childhood would not be prevented. The cost to prevent perinatal HBV infection is $12.6 million, and the cost to vaccinate infants is $47 million. The cost of vaccination and administration is higher for adolescents than for infants. The cost to prevent each chronic HBV infection is $12,744 for adolescent vaccination compared to $6,111 for routine infant vaccination, and $900 for perinatal HBV infection.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1995
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Hepatitis C virus infection associated with administration of intravenous immune globulin: a cohort study
Article Abstract:
An intravenous immune globulin (IGIV) under the trade name Gammagard appears to be associated with several cases of hepatitis C infection. IGIV is produced from human blood and is given to people with immune deficiencies. Researchers tested 278 people who received IGIV between Mar 1993 and Feb 1994, of whom 210 received Gammagard and 52 received another IGIV product. Twenty-three of those who received Gammagard tested positive for hepatitis C virus but none of those who took other products contracted the virus. This occurred even though the blood products from which Gammagard was produced had been screening for hepatitis C virus.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996
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Reye's syndrome in the United States from 1981 through 1997
Article Abstract:
The incidence of Reye's syndrome has dropped dramatically since it was first linked to aspirin use in children with influenza or chickenpox. Reye's syndrome is characterized by liver degeneration and brain dysfunction. In 1980, when the link to aspirin was first discovered, there were 555 cases of Reye's syndrome in children. However, since 1987, the number of cases per year has never exceeded 36. Between Dec, 1980 and Nov, 1997, there were 1,207 cases, 31% of which were fatal. Children under the age of five and those with severe liver dysfunction had the highest mortality rates.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
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