Prognostic value of immunohistochemically identifiable tumor cells in lymph nodes of patients with completely resected esophageal cancer

Article Abstract:

A monoclonal antibody against a specific tumor antigen appears to be capable of detecting metastatic esophageal cancer in lymph nodes that was missed by a pathologist during microscopic examination of tissue samples. Researchers used the Ber-EP4 monoclonal antibody to detect metastatic esophageal cancer in 399 lymph nodes from 68 patients who had surgery for their cancer. All the nodes were considered tumor-free by a pathologist. Seventeen percent tested positive using the monoclonal antibody. Patients from whom these lymph nodes were taken had lower survival rates and higher relapse rates.

Medical examination, Monoclonal antibodies, Lymph nodes, Esophageal cancer, Lymphatic metastasis

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Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer

Article Abstract:

Bone marrow biopsies can be tested with monoclonal antibodies against a protein called cytokeratin. This protein occurs on the surface of epithelial cells that have metastasized to bone. The test can therefore detect women with breast cancer that has spread to the bone. In a study of 552 women with breast cancer, 25% of those with a positive test died, compared with 6% of those with a negative test. This was true even in women with no lymph node metastasis. Fourteen percent of those who tested positive died compared to 1% of those who tested negative.

Breast cancer

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Micrometastases and survival in stage II colorectal cancer

Article Abstract:

An assay that detects carcinoembryonic antigen in tissue samples can identify early metastasis in colorectal cancer patients. Carcinoembryonic antigen is a protein that occurs in cancerous tissue but not normal tissue. Researchers used this assay on 192 lymph nodes from 26 patients with colorectal cancer but no lymph node metastasis. The assay detected microscopic metastasis in half of these patients. The five-year survival rate for these patients was 36%, compared to 75% in patients without microscopic metastasis.

Colorectal cancer, CEA (Oncology), Carcinoembryonic antigen

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