Prostaglandin endoperoxide synthetase isoenzymes: the clinical relevance of selective inhibition

Article Abstract:

Inhibition of one of two cyclo-oxygenases may become more specific through the development of new non-steroidal anti-inflammatory drugs (NSAIDs). The two cyclo-oxygenases, known as COX I and COX II, synthesize prostaglandins, which promote inflammation, and COX I may be involved in body functions that require prostaglandins. COX I promotes blood clotting and may prevent the development of stomach ulcers. COX II is produced by the uterus and placenta during pregnancy and may activate increased prostaglandin production in response to inflammation. COX II has therefore been singled out for inhibition by drug therapy. Ibuprofen, diclofenac, and 6-MNA inhibit COX II most effectively. A new drug, meloxicam, may specifically target COX II more than other drugs. Scientists hope to soon identify an NSAID that does not cause gastrointestinal problems.

Health aspects, Nonsteroidal anti-inflammatory drugs, Nonsteroidal anti-inflammatory agents, Prostaglandins, Prostaglandin synthesis

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Biopsy proven and biopsy negative temporal areteritis: differences in clinical spectrum at the onset of the disease

Article Abstract:

Cases of arteritis which are able to be proven by biopsy seem to be more severe than those which are negative at both the time of diagnosis and the follow up and seasonal differences may account for some of the differences. Of 207 proven biopsies and 85 negative one, 58% of the proven cases were diagnosed during the autumn or winter as compared to 39.29% of the negative cases diagnosed during autumn of winter. Visual problems including blindness, jaw claudication, and temporal artery palpation abnormalities were more common in the proven group.

Diagnosis, Seasonal variations (Diseases), Biopsy, Arteritis

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Prevalence and clinical features of cryoglobulinaemia in multitransfused Beta-thalassaemia patients

Article Abstract:

The authors address aspects of this hereditary form of anemia, specifically the presence of cryoglobulinemia, an abnormal protein in the blood of those patients who have had multiple transfusions. It was found in 66% of the patients who had chronic hepatitis C, a large enough number to suggest it be considered as possible when thalassemia is being diagnosed.

Care and treatment, Thalassemia, Cryoglobulinemia

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