RIGing a virus trap
Article Abstract:
A report that retinoic acid-inducible gene I (RIG-I) induces type I interferon (IFN-alpha/beta) in several cell types infected with RNA viruses, but toll-like receptors (TLR) signaling, is dominant in plasmacytoid dendritic cells, highly specialized cells that make extraordinary high levels of IFN-alpha/beta is presented. RIG-I-deficient mice are generated in order to access the importance of RIG-I in regulating the IFN-alpha/beta response.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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NKCC1 transporter facilitates seizures in the developing brain
Article Abstract:
The hypothesis that in the immature brain, before physiological expression of KCC2, alteration of the ionic basis for GABA-mediated excitation by diuretic drugs inhibits seizure activity in the immature brain is presented. Results provide evidence that NKCC1 facilitates seizures in the developing brain and indicate that bumetanide should be useful in the treatment of neonatal seizures.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Side benefits sway developing nations to choose unneeded vaccine
Article Abstract:
Global health agencies provide vaccines, health supplies and funds for delivering vaccines to developing countries. Many nations accept the attractive packages offered by the agencies even if the vaccines are unwarranted by disease prevalence.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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