Race and the response to adrenergic blockade with carvedilol in patients with chronic heart failure

Article Abstract:

Both black and white patients with heart failure appear to benefit from the beta blocker carvedilol, according to a study of 217 black and 877 white patients. Black patients with heart failure generally have a worse outcome than whites and may not respond to medications in the same way as whites.

Research, Health, Health and race, Ethnic groups

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Effect of carvedilol on survival in severe chronic heart failure

Article Abstract:

The beta blocker carvedilol reduced the risk of death by 35% in a study of 2,289 patients with severe heart failure. It also reduced the rate of hospitalization for a worsening of symptoms.

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The effect of carvedilol on morbidity and mortality in patients with chronic heart failure

Article Abstract:

Carvedilol appears to reduce mortality from heart failure. Carvedilol is a beta blocker that also affects alpha1 receptors. Of 1,094 people with chronic heart failure, 696 took approximately 45 milligrams of carvedilol every day and 398 took a placebo. Most of the participants were taking other heart medications. Treatment lasted up to 15 months. Three percent of the patients taking carvedilol died compared to 8% of those in the placebo group. Hospitalization rates were 27% less in the carvedilol group compared to the placebo group. Heart rate dropped significantly in those taking carvedilol but blood pressure remained the same in both groups. Dizziness was the most common side effect of carvedilol followed by fatigue and shortness of breath. Only 6% of those taking carvedilol had to stop taking the drug because of side effects. Other beta blockers may not have the same effect on mortality as carvedilol.

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