Reappraising the value of urine leukocyte esterase testing in the age of nucleic acid amplification

Article Abstract:

The urine leukocyte esterase (LE) test may still be effective in identifying men who do not require further testing for urethritis. This test detects certain white blood cells in urine samples, which in men indicates the presence of urethritis, an infection of the urethra. In a study of 301 men that compared the LE test to polymerase chain reaction (PCR) testing of urine samples, the LE test was not very effective in detecting men who had urethritis but was very effective in detecting men who did not. Therefore, using the cheaper LE test first could result in significant cost savings.

Evaluation, Diagnosis, Measurement, Medical screening, Health screening, Neutrophils, Urethritis

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The acceptability of oral fluid testing for HIV antibodies: a pilot study in gay bars in a predominantly rural state

Article Abstract:

Analysis of oral fluids using the OraSure HIV-1 oral specimen collection device could increase the acceptability of HIV testing in some populations. Many people at risk of HIV do not visit traditional sites that provide HIV testing and some people are afraid of needles. Researchers used the OraSure kit to test 118 men in gay bars. Half of the men agreed to be tested and 6% tested positive. This was the first time 22% of the men had been tested. Over 90% believed testing in gay bars was an acceptable alternative to traditional test sites.

Usage, Testing, Saliva, Gay men, OraSure (Medical test kit)

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Sensitivity and Specificity of HIV-1 Testing of Urine Compared With Serum Specimens: Rakai, Uganda

Article Abstract:

The Calypte HIV-1 Urine enzyme immunoassay (EIA) with Western blot (WB) confirmation appears to be an effective HIV test. This was the conclusion of a study that compared the urine test with traditional blood tests. Many patients were more comfortable giving urine samples than blood samples. The urine test detected 95% to 100% of the HIV infections detected by the blood test, depending on whether the urine was fresh or had been stored prior to testing. The urine test also accurately detected over 90% of the people who were HIV-negative.

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