Regulation of osteoclast differentiation and function by the CaMK-CREB pathway

Article Abstract:

The effects of pharmacological inhibition of CaMKs were investigated by using an in vitro osteoclast culture system to test whether the role of C[a.sub.2.plus]/calmodulin in osteoclastogenesis is mediated through CaMKs. The CaMK-CREB pathway biphasically functions to regulate the transcriptional program of osteoclastic bone resorption by not only enhancing induction of NFATc1 but also facilitating NFATc1-dependent gene regulation once its expression is induced.

Japan, Physiological aspects, Cell differentiation, Cyclic adenylic acid, Cyclic adenosine monophosphate, Osteoclasts (Biology)

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Selective inhibition of NF-kappa blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

Article Abstract:

Blocking NF-kappa B is believed to be potential strategy to prevent inflammatory bone resorption. However, extensive pharmacological evaluation is required to understand the effects of long-term use of NBD peptide to treat chronic inflammatory diseases.

Care and treatment, Evaluation, Risk factors, Chronic diseases, Osteogenesis imperfecta, Pharmacology, Experimental, Pharmacological research

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NFAT and Osterix cooperatively regulate bone formation

Article Abstract:

The administration of FK506 is responsible for inducing the reduction of bone mass in spite of a blockade of osteoclast differentiation. Osteoblastic bone formation is cooperatively controlled by nuclear factor of activated T cells (NFAT) and Osterix.

United States, Science & research, Research, Usage, Bones, Bone density, Immune response, Immunosuppressive agents

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