Responses of synovial fluid and peripheral blood mononuclear cells to bacterial antigens and autologous antigen presenting cells
Article Abstract:
Bacterial antigens do not appear to elicit a greater response in the synovial fluid of patients with rheumatoid arthritis (RA) than in patients with other rheumatic diseases. The responsiveness of synovial fluid and peripheral blood to bacterial antigens such as those from Mycobacterium and Streptococcus was measured in samples of synovial fluid and peripheral blood from 20 patients with RA, 12 patients with other rheumatic disorders, two patients with juvenile rheumatoid arthritis and 10 healthy individuals. There were no significant differences between patients with rheumatoid arthritis and those with other rheumatic diseases in their response to any of the bacterial antigens. However within each group of patients, samples of synovial fluid were significantly more responsive to bacterial antigen than were samples of peripheral blood. Furthermore, antigen presenting cells in synovial fluid stimulated T cells in peripheral blood even without antigens being present, suggesting their importance in mediating inflammatory joint diseases.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1993
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Increased serum and synovial fluid antibodies to immunoselected peptides in patients with rheumatoid arthritis
Article Abstract:
Immune reactions between body fluid samples and known and sequenced synthetic peptides in peptide libraries may help to identify the peptide components responsible for the chain of events that occur in rheumatoid arthritis (RA). Peptides are the building blocks of proteins. Samples of blood and synovial fluid from patients with RA and healthy volunteers were combined with a series of peptides suspected of participating in the immune response characteristic of RA. There were stronger immune reactions in the samples from the RA patients compared to the healthy volunteers.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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Examination of synovial fluid and serum hyaluronidase activity as a joint marker in rheumatoid arthritis and osteoarthritis patients (by zymography)
Article Abstract:
The enzyme hyaluronidase may be an indicator of joint inflammation in arthritis. Hyaluronic acid is a polysaccharide found most prominently in connective tissue and joint synovial fluid. Researchers compared hyaluronidase activity in 39 patients with rheumatoid arthritis and 42 patients with osteoarthritis, and healthy people. Hyaluronidase activity was higher in rheumatoid arthritis patients, and higher activity was associated with higher blood levels of C reactive protein and the concentration of blood platelets, indicators of rheumatic disease activity.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1999
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