Restenosis revisited - new targets, new therapies
Article Abstract:
The prevention of re-stenosis after coronary angioplasty has been hard to achieve. Angioplasty is used to remove fatty plaques in the coronary arteries, but the plaques sometimes return, a condition called re-stenosis. A 1997 study found that the antioxidant drug probucol significantly reduced re-stenosis in a group of patients who had angioplasty. Unfortunately, probucol is no longer available in the US because it was shown to be ineffective in the treatment of atherosclerosis. Vitamins do not appear to be effective in preventing re-stenosis. The best goal may be to prevent atherosclerosis, which would eliminate the need for angioplasty.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
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Local delivery of paclitaxel to inhibit restenosis during angioplasty of the leg
Article Abstract:
A study to examine the efficacy of paclitaxel on restenosis after angioplasty of the leg is conducted. Results indicate that paclitaxel-coated angioplasty balloons showed significant reductions in target-lesion revascularization as compared to paclitaxel-containing contrast medium.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2008
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