S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide
Article Abstract:
An attempt is made to demonstrate that NO-derived peroxynitrite (ONOO-) directly increase SERCA activity by S-glutathiolation and that this modification of SERCA is blocked by irreversible oxidation of the relevant cysteine thiols during atherosclerosis. Results of the study indicate the physiological relevance of S-glutathiolation in regulating SERCA activity during NO-induced arterial relaxation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
Article Abstract:
A novel mechanism for the regulation of nitric oxide (NO) production in endothelial cells in disease is described. It is shown that G-protein-coupled receptor kinase-2 (GRK2) interacts directly with Akt, and that this interaction inhibits phosphorylation of Akt, which results in reduced activation of endothelial cell NO synthase (eNOS) and thus reduced NO production.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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The survival kit of Mycobacterium tuberculosis
Article Abstract:
Whole-genome expression profiling is used to investigate the transcriptional response of Mycobacterium tuberculosis to nitric oxide (NO). The analysis has underscored the breadth and elegance of the tactics used by Mycobacterium tuberculosis to ensure its survival in the intracellular environment.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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