Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
Article Abstract:
The tumor-suppressor function in tumors that retain wild-type p53 is often impaired because of the deregulation of HDM-2, which binds to p53 and targets it for proteasomal degradation. A chemical library and identification of a small molecule named RITA is screened, which is bound to p53 and induces its accumulation in tumor cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Saving face: rescuing a craniofacial birth defect
Article Abstract:
The rescuing of the various craniofacial birth defects in humans by the inhibition of the tumor suppressor p53 is discussed. The analysis shows that the technique can also be used effectively for the prevention of the Treacher Collins syndrome.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2008
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