Somatostatin regulates brain amyloid beta peptide Abeta(sub 42) through modulation of proteolytic degradation
Article Abstract:
Somatostatin regulates the metabolism of amyloid beta peptide (Abeta), the primary pathogenic agent of Alzheimer disease, in the brain through modulating proteolytic degradation catalyzed by neprilsyn. The results indicate that the aging-induced downregulation of somatostatin expression may be a trigger for Abeta accumulation leading to late-onset of sporadic Alzheimer disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides
Article Abstract:
The potential role of apolipoprotein E (Apoe) in astrocyte-mediated degradation in brain is investigated. The results propose that Apoe is important in the degradation and clearance of deposited amyloid-beta (Abeta) peptides by astrocytes, a process that may be impaired in Alzheimer disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Identification of the major Abeta(sub)(1-42)-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition
Article Abstract:
A neutral endopeptidase similar or identical to neprilysin degrades amyloid beta-peptide. This peptide accumulates abnormally in patients with Alzheimer's disease, and the endopeptidase could be used therapeutically to prevent this accumulation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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