Suppressing the self in rheumatoid arthritis
Article Abstract:
Rheumatoid arthritis cause chronic inflammation of peripheral joints, cartilage destruction and bone erosion in about 1 percent of human population and its treatment though slows down the disease progression but has serious side effects. A mouse with collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis was studied by injecting it with monoclonal antibodies to CD137 (4-1 BB), a T-cell costimulatory receptor.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
VIP: a very important protein in arthritis
Article Abstract:
Research presented finds that inflammatory arthritis can be suppressed by the introduction of the vasoactive intestinal peptide (VIP). Topics include the pathogenesis of rheumatoid arthritis, the anti-inflammatory effects of VIP, and how the protein can regulate innate and adaptive immune responses to arthritis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Evolving concepts of rheumatoid arthritis
Article Abstract:
Rheumatoid arthritis (RA) is symmetric polyarticular arthritis and is a major cause of disability. Specific therapeutic interventions can be designed based on the pathogenic mechanism to suppress synovial inflammation and joint destruction in rheumatoid arthritis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Neuroprotective autoimmunity -- a double-edged sword?
- Abstracts: Piercing the pain. What you think of doctors. How to make yourself just the job
- Abstracts: A professional response to demands for accountability: practical recommendations regarding ethical aspects of patient care
- Abstracts: Join the celebration. First things first
- Abstracts: The poet in every child. 5 activities to do in September