Sweet relief for Huntington disease
Article Abstract:
The oral intake of a non-toxic sugar molecule prevents development of brain pathology, associated with Huntington disease and alleviates the symptoms of the disease in mouse models. Clinical and genetic similarities imply that polyglutamines induce toxicity, although loss of the normal function of causative proteins may influence the disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Trehalose alleviates polyglutamine - mediated pathology in a mouse model of Huntington disease
Article Abstract:
The oral administration of trehalose, an effective disaccharide lessens the polyglutamine aggregation, thus providing a new therapeutic method for polyglutamine diseases and increases life span in a mouse model in Huntington disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
Article Abstract:
Research presented suggests minocycline can delay Huntington disease progression by inhibiting caspase-1 and caspase-3 upregulation and expression. Topics addressed include genetic mutations and cellular control mechanisms.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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