Testing models predicting severity of respiratory syncytial virus infection on the PICNIC RSV database
Article Abstract:
A set of predictive factors developed from analysis of medical studies appears to do a reasonable job of predicting which children would have serious respiratory syncytial virus (RSV) infections. RSV is a common cause of generally mild lung infections in young children. It would be useful to know which children were likely to develop serious infections so as to target expensive and complex therapies. Predictive factors alone and in concert were developed from studies of RSV infections and then applied to a database of 689 children admitted to hospitals for RSV infections. Single predictors such as young age, prematurity at birth, and congenital heart disease accurately predicted 17% of children who would have longer stays, be admitted to intensive care, or require ventilation. When multiple factors were considered, the accuracy of identifying which children would have serious infections exceeded 90%.
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 1995
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Impact of Respiratory Syncytial Virus Immune Globulin in 1996-1997
Article Abstract:
Respiratory syncytial virus (RSV) immune globulin may prevent RSV infections requiring hospitalization in some premature infants with lung disease. Researchers compared RSV hospitalization rates in 76 infants treated with immune globulin and 112 not given the antibody-rich treatment. In children without chronic lung disease, 3-4% required hospitalization for RSV infection, regardless of treatment status. In children with lung disease, 5% of treated children and 11% of untreated children developed serious RSV infections. Premature birth, lung disease, and other clinical characteristics may best indicate which children may benefit from preventive therapy with RSV immune globulin.
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 1999
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A number-needed-to-treat analysis of the use of respiratory syncytial virus immune globulin to prevent hospitalization
Article Abstract:
Treatment with respiratory syncytial virus (RSV) immune globulin (IG) may not prevent enough hospitalizations for RSV infection to justify widespread therapeutic use. Researchers analyzed three randomized clinical trials of RSV-IG to determine the costs and benefits of the treatment. Overall, 16 children would require RSV-IG treatment to prevent the hospitalization of one child. RSV-IG treatment may cost as much as $5000 per child. This treatment may not be cost-effective in routine use for children without lung disease.
Publication Name: Archives of Pediatrics & Adolescent Medicine
Subject: Health
ISSN: 1072-4710
Year: 1998
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