The association between midlife blood pressure levels and late-life cognitive function: the Honolulu-Asia Aging Study
Article Abstract:
High blood pressure in middle age may be a risk factor for cognitive impairment in old age. Researchers gave cognitive tests to 3,735 Japanese-American men who were part of the Honolulu Heart Program. The men had been born on Oahu between 1900 and 1919 and were followed up regularly. They were grouped according to their recorded systolic and diastolic blood pressure (SBP and DBP) when they were middle aged. Men with high blood pressure in midlife were more likely to have intermediate to poor cognitive function compared to those with normal blood pressure. This increased risk of cognitive impairment was seen only in those with high SBP. There was no association between DBP and cognitive impairment. Many of the men with high blood pressure had normal blood pressure in midlife. Treatment for high blood pressure in middle age could reduce the economic impact of dementia in the elderly.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1995
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Midlife Hand Grip Strength as a Predictor of Old Age Disability
Article Abstract:
Poor muscle strength in middle age may predict which patients will develop functional disabilities in old age. Researchers analyzed disability rates in 3,218 elderly people in the Honolulu Heart Program who had had their hand grip strength measured during middle age. Those who had the weakest hand grip during middle age were twice as likely to be functionally disabled in old age as those with the strongest hand grip. This risk was independent of other risks for disability such as chronic disease.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
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Midlife risk factors and healthy survival in men
Article Abstract:
Prospective cohort study is conducted to test whether midlife biological, lifestyle, and sociodemographic risk factors are associated with overall survival and exceptional survival. The results have shown that avoidance of certain risk factors in midlife is associated with the probability of a long and healthy life among men.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
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