The cloning and clinical implications of HGV and HGBV-C

Article Abstract:

It may be premature to indict the hepatitis G virus (HGV) and its GB variant (HGBV) as a major cause of hepatitis. HGV and HGBV were identified in 1995 using the polymerase chain reaction on blood samples from several people with hepatitis. Their gene sequences are 95% identical so they are considered closely related. However, they have only 25% sequence identity with hepatitis C, which makes them a new genus in the Flavivirus family. They are transmitted by blood transfusions and have also been identified in intravenous drug addicts and people receiving hemodialysis. They are very hard to detect because they do not induce the formation of antibodies. Several studies have shown that HGV and HGBV do not cause liver disease, even in people who have been infected for long periods of time. Other people have continued to test positive even after they recover from acute hepatitis. Until further studies are done, these viruses should be considered relatively harmless.

Identification and classification, Hepatitis viruses

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Clinical features of 52 neonates with hyperinsulinism

Article Abstract:

Some newborn infants with hyperinsulinism can be treated by removing small parts of the pancreas rather than the entire pancreas. Hyperinsulinism occurs when the pancreas produces too much insulin, which can cause hypoglycemia, or low blood sugar. Researchers used catheters to determine whether 52 newborn infants with hyperinsulinism had widespread pancreatic damage or damage that only affected a small area of the pancreas. Thirty infants with widespread damage had their entire pancreas removed and only two had normal blood sugar levels one year later. The remaining 22 had part of the pancreas removed and all had normal blood sugar levels one year later.

Care and treatment, Surgery, Diseases, Infants (Newborn), Neonatal diseases, Pancreas, Hypoglycemia

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The clinical significance of fusion oncogenes in cancer

Article Abstract:

Fusion of genes and the resultant production of fused proteins is a process identified in some soft-tissue and blood cell cancers. Different fusions, sometimes in the same genes, seem related to the type of tumor produced. This discovery in the molecular biology of cancer may prove useful in the development of diagnostic and prognostic indictors of tumors. Steps in these fusion and protein production processes may be appropriate targets for cancer screening tests or cancer treatment therapies.

Health aspects, Genetic aspects, Cancer, Cancer genetics, Gene fusion

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