The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy
Article Abstract:
Research presented concerns human immunodeficiency virus 1 (HIV-1) replication and the physiological effects of prolonged anti-retroviral therapy. Findings suggest that HIV-1 persists in patients involved in long-term anti-retroviral therapy because of the slow decay characteristics of replication-competent HIV-1.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif
Article Abstract:
Research reveals that the human protein apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) has dual function in HIV pathogenesis. It can inactivate the virus by gaining entry into progeny virions, which is prevented by the HIV-1 virion infectivity factor (Vif) protein, as well as undergoes Vif induced ubiquitination and degradation by the proteasome.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Latent reservoirs of HIV infection: flushing with IL-2?
Article Abstract:
It may be possible to further dilute quantitites of infectious HIV in infected people by using both potent anti-retroviral therapy and immune therapy using interleukin-2, based on recent study. Failure of potent anti-retroviral therapy to get HIV infection out may be the result of a rather small pool of infected, long-lived dormant T cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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