The efficacy of intensive dietary therapy alone or combined with lovastatin in outpatients with hypercholesterolemia

Article Abstract:

A combination of diet therapy and lovastatin may not be more effective than treatment with lovastatin alone in patients with hypercholesterolemia, or increased blood levels of cholesterol. Diet therapy for hypercholesterolemia involves a diet low in saturated fat and cholesterol. Ninety-seven patients with moderate hypercholesterolemia participated in four nine-week periods of treatment with a low-fat diet and lovastatin, a high-fat diet and lovastatin, a low-fat diet and a placebo (an inactive substance) and a high-fat diet and a placebo. The low-fat diet alone only reduced low-density lipoprotein (LDL) cholesterol by 5%, but lovastatin alone reduced LDL cholesterol 27%. Together, they reduced LDL cholesterol by 32%. However, the low-fat diet blocked the drug-induced increase in blood levels of high-density lipoprotein (HDL) cholesterol. This may interfere with the positive effects of drug therapy.

Care and treatment, Usage, Hypercholesterolemia, Diet therapy

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Efficacy and Safety of Lovastatin in Adolescent Males With Heterozygous Familial Hypercholesterolemia: A Randomized Controlled Trial

Article Abstract:

Boys with hereditary hypercholesterolemia may benefit from treatment with lovastatin. Hypercholesterolemia is the medical term for excessive blood cholesterol levels. Researchers randomly assigned 132 boys with hereditary hypercholesterolemia to take lovastatin or a placebo every day. The dose of the drug began at 10 milligrams per day and was increased as high as 40 milligrams. Lovastatin lowered blood levels of LDL, or `bad' cholesterol and did not appear to adversely affect growth or sexual maturity.

Evaluation, Drug therapy, Hypercholesterolemia in children, Pediatric hypercholesterolemia

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A large high-density lipoprotein enriched in apolipoprotein C-I

Article Abstract:

A study is conducted to determine if there are any novel patterns of lipoprotein heterogeneity in low-birth-weight infants. The results suggest that as apolipoprotein C-I-enriched high density lipoprotein, and purified apolipoprotein C-I alone promotes apoptosis in vitro, increased amounts of this particle might have physiological significance and identify a novel group of low-birth-weight infants apparently distinct from traditionally classified small-for-gestational-age infants.

Science & research, Research, Birth weight, Low, Low birth weight, Infants (Newborn), Newborn infants, Apolipoproteins

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