The total artificial heart
Article Abstract:
This article presents the recent advances in the field of total artificial heart designing and construction and its use in the artificaial heart transplantation procedures. The first total artificial heart, the Liotta, fabricated in 1969 is followed by the Akutsu in 1981 and Jarvik-7 five years later. The latest versions are the AbioCor and the Sarns with the former being currently evaluated.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Histidine button engineered into cardiac troponin I protects the ischemic and failing heart
Article Abstract:
The substitution of a single histidine residue present in the fetal cardiac Tnl isoform into the adult cardiac Tnl isoform at codon 164 results in the enhancement of cardiac performance in vitro and in vivo. Systolic and diastolic function is improved and reperfusion-associated ventricular arrhythmias are mitigated by the histine-modified Tnl in the isolated heart.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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