The matrix degrades, neutrophils invade
Article Abstract:
A study focuses on an acetylated tripeptide derived from proteolytic cleavage of collagen and shows how this tripeptide serves in the lung as a chemoattractant for neutrophils and may also have a role in chronic obstructive pulmonary disease (COPD). COPD is primarily a systemic inflammatory disease of the lung, induced by cigarette smoke and is characterized by the presence of emphysema and chronic bronchitis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
Article Abstract:
Interleukin-8 (IL-8) has promoted bacterial killing by neutrophils through the chemokine receptor CXCR1 not CXCR2. The cleavage of CXCR1 and the identification of soluble CXCR1 fragments behaving like bioactive components have represented a new pathophysiologic mechanism in cystic fibrosis and other chronic lung diseases.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Reversing systematic inflammatory response syndrome with chemokine receptor pepducins
Article Abstract:
A new therapeutic approach for the treatment of lethal sepsis using cell-penetrating lipopeptides termed pepducins that target either individual or multiple chemokine receptors is described. Interleukin-8(IL-8), a ligand for the CXCR1 and CXCR2 receptors, is the most potent endogenous proinflammatory chemokine in sepsis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Causes and management of chronic breathlessness in adults. Understanding why we use spirometry: part one. Chronic obstructive pulmonary disease
- Abstracts: Nursing practice violations: What's your response? Screening for pain
- Abstracts: The way to take charge. Improving information for men with postoperative urinary incontinence
- Abstracts: Teaching others new skills can aid your own learning. Reviewing the effectiveness of tympanic thermometers
- Abstracts: Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma