Placental pathologic features of preterm preeclampsia

Article Abstract:

The preterm placentas of pregnant women with preeclampsia may sustain more chronic inflammatory lesions and lesions involving blood coagulation than do preterm placentas of women without preeclampsia. Preeclampsia is a complication of pregnancy involving high blood pressure and protein in the urine. Researchers studied the placentas of infants born between 22 and 32 weeks of pregnancy. Seventy-six mothers had preeclampsia and 353 did not. The inflammatory lesions and lesions involving coagulation may be representative of the disease processes of preeclampsia. In turn, abnormal development of the placenta may trigger preeclampsia. Inflammation of the placenta may lead to uterine contractions and preterm delivery. Such findings may further research into treatments for preeclampsia that preserve the mother's and fetus's health.

Physiological aspects, Preeclampsia, Inflammation, Umbilical cord

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Relationship between placental histologic features and umbilical cord blood gases in preterm gestations

Article Abstract:

Placental lesions may reduce the respiratory function of the placenta, causing the fetus to experience a chronic lack of oxygen and stunted growth. Researchers studied 431 placentas and fetuses born between 22 and 32 weeks' gestation. Lesions of blood vessels and villous lesions in the placenta and uterus were thought to restrict blood and fluid flow and were associated with poor blood gas values. Preterm placentas without lesions may be less able to withstand the stress of labor than term placentas, as evidenced by the greater incidence of fetal distress among fetuses delivered preterm. Fetuses whose placentas have lesions that compromise placental function may adapt to the lack of oxygen and not show the signs of distress during labor that fetuses with healthier placentas may exhibit.

Analysis, Fetal blood, Blood gases, Blood gas analysis

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