The use of the GnRH analogue buserelin for IVF - does it improve fertility?

Article Abstract:

In vitro fertilization (IVF) is gaining popularity as a method of achieving pregnancy in infertile couples. This method involves collecting eggs and sperm, and then combining them in a test tube. The standard procedure for collecting the eggs involves treating the woman with clomiphene citrate (CC) from day two to day seven of the menstrual cycle. Treatment with human menopausal gonadotropin (hMG) is started on day five of the cycle. When the amount of luteinizing hormone (LH) increases (called the LH surge), an injection of human chorionic gonadotrophin is given (hCG). This stimulates ovulation (the release of mature eggs from the ovaries into the fallopian tubes) and the eggs are collected approximately 35 hours after treatment with hCG. Within recent years, a new drug called buserelin has been used for IVF. This drug has several advantages over CC. It increases the number of follicles (eggs) in the ovaries and prevents the levels of LH from becoming to high. A study was performed to compare the effectiveness of buserelin with CC in achieving IVF. The study included 373 infertile couples. The women were less than 46 years of age and had normal menstrual cycles. One hundred and fifty-one women were treated with CC and hMG (using the regimen described above), and 222 were given buserelin and hMG (buserelin on days one through three and hMG beginning on day two of the cycle). Approximately 20 percent of the women from each drug group had a poor response or did not respond at all to treatment. Thirty-eight percent of the women treated with buserelin became pregnant and 35 percent of those treated with CC became pregnant. Although treatment with buserelin stimulated the development of more follicles and reduced the levels of LH, buserelin was no more effective than CC in achieving pregnancy through IVF. Treatment with buserelin may have advantages for older women who have high levels of LH and for whom follicle development is harder to stimulate. (Consumer Summary produced by Reliance Medical Information, Inc.)

Evaluation, Infertility, Female, Female infertility, Fertility agents, Fertility drugs, Clomiphene

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Exercise on prescription: does it work?

Article Abstract:

Recent research has analysed the 'Stockport Exercise on Prescription Scheme,' giving particular attention to changes in physical and mental health and to patterns of compliance. It was found that participants enjoyed considerable mental and physical benefits, even though compliance dropped to very low levels after an initial period. Future research must look at ways of encouraging more people to participate.

Research, Exercise therapy

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A tale of stolen embryos: inside a nightmare fertility clinic

Article Abstract:

Doctors at a successful fertility clinic affiliated with the Univ of California at Irvine harvested embryos from women and gave them to other women. Three clinic workers who blew the whistle are profiled, and other clinic improprieties are discussed.

University of California (Irvine)

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