Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A)
Article Abstract:
The introduction of extra copies of Charcot-Marie-Tooth disease (CMT) gene, Pmp22 (peripheral myelin protein of 22 kDa) into transgenic rats, had generated a model of CMT, subtype 1A (CMT-1A). The model was tested to study the modulation effect of progesterone on neuropathy caused by moderate overexpression of Pmp22.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
Article Abstract:
Research presented concerns immunological tolerance and the physiological mechanisms that protect against autoimmune diseases. Topics addressed include T-cell tolerance to proteolipid protein, and susceptibility to multiple sclerosis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
Article Abstract:
The authors point out that while T cells can contribute to autoimmune diseases, they can also be protective. In the instance of a partially crushed optic nerve, specific T cells prevented further deterioration.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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