Therapy for human immunodeficiency virus infection

Article Abstract:

Avariety of drugs are used to treat individuals with HIV infection. Many of the drugs used to treat HIV infection interfere with the replication process of HIV-1. Zidovudine (AZT) has been successful in delaying the progression of HIV infection and prolonging the lives of HIV-infected individuals. Resistance to zidovudine can develop with long-term treatment. Didanosine and zalcitabine are two other drugs that interfere with the progression of HIV infection. Didanosine has been approved by the Food and Drug Administration (FDA) for the treatment of HIV infection, but zalcitabine can only be used in combination with zidovudine. Several new drugs are being tested for the treatment of HIV infection. These drugs include reverse transcriptase inhibitors, tat protein inhibitors and protease inhibitors. Combination therapy is also being tested. This type of therapy involves simultaneous treatment with several different drugs.

Health aspects, Protease inhibitors, Didanosine

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Antiretroviral Drug Resistance Testing in Adults With HIV Infection, Part 3

Article Abstract:

Genetic testing of the virus in HIV-infected patients may be useful in guiding antiviral drug therapy to maximize effectiveness and reduce development of drug resistance. A panel of experts assembled by the International AIDS Society - USA recommends viral load and CD4+ T-cell count as immunologic guides for antiretroviral drug therapy. Poor patient compliance with treatment protocols contributes to the development of drug-resistant HIV. Resistance testing may be useful for determining the optimal drugs for use in treatment.

Reports, Prevention, Physiological aspects, HIV (Viruses), HIV, Genetic aspects, Drug resistance in microorganisms, Microbial drug resistance, Antiviral agents, International AIDS Society

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Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection

Article Abstract:

Giving HIV patients three drugs from two drug classes is as effective as giving them four drugs from three drug classes, according to a study of 980 patients. Three drugs will have fewer side effects and may be easier to take than four drugs. In this study, zidovudine, lamivudine, and efavirenz were the best three drugs for newly diagnosed HIV patients to start with.

Evaluation, Lamivudine

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